Of these 6 patients, 1 reported prescription medication use ondansetron4 reported Garzon Older asian sex women having in medication use, and 1 was unknown. This study was self-funded by the Singapore Cardiac Data Bank. Our results also suggest that pre-eclampsia and placenta previa may be potential risk factors for PHACE syndrome, but further work is needed to distinguish their impact on the development of infantile hemangiomas alone versus PHACE syndrome specifically. The prominent effect of age is consistent with the reversed sex effect in patients with diabetes from prior reports [ 42437 ]. World Health Org; Reddy KS, Yusuf S. No patients reported near miscarriage, and 1 patient reported bleeding due to her low-lying placenta. We observed significantly higher reported rates of pre-eclampsia and placental abnormalities, specifically placenta previa, in our cohort of PHACE syndrome patients than in the general population, suggesting that these complications may be potential risk factors for PHACE syndrome.